Logo Ncode color

Antigen design and sequence optimization

Ncode, the advanced Quantoom bioinformatic platform, turning any antigen to optimized RNA ready for efficient therapeutics in real-world production.

Quantoom is your sole partner of trust for RNA-based therapeutics with increased DNA manufacturability, enhanced RNA stability and prolonged antigen expression.

+300
RNA designs generated on the platform
+100
tested in vitro & in vivo
100%
successfully inducing protein expression

What is Ncode?

Much more than a software tool, Ncode combines a powerful computational engine with the scientific expertise of our bioinformaticians, computational biologists, and RNA scientists.

Strand 01

Machine precision

State-of-the-art algorithms, computational models and AI-driven optimization explore vast sequence design spaces at a remarkable speed and scale, no human could reach alone.

Strand 02

Human intelligence

Every output is shaped by hands-on scientific review, ensuring our platform products are biologically meaningful and practically viable, not just computationally optimal.

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The first pillar of N-Force

Ncode
RNA design platform
Ntensify®
RNA production platform
Ncapsulate®
RNA delivery platform

Ncode is the design pillar of N-Force where every RNA production begins. Ncode hands the new biologic off to Ntensify® for production at every scale, and Ncapsulate® for delivery of the drug product.

Our capabilities

From sequence landscape to production-ready RNA, three connected stages, one design engine.

Neoantigen / string-of-beads design
Mosaic world coverage
01

Antigen design support

When the antigen is not yet defined, Ncode can support antigen design for selected applications, bringing computational and biological expertise to the first critical step of an RNA-based treatment.

Personalized cancer treatments — neoantigen assembly
Starting from candidate neoantigens provided to us, our domain experts design the constraints that drive neoantigen assembly, optimizing their encoding to maximize processing and generate RNA-ready sequences, patient by patient.
Animal health — mosaic antigen design
Sequence data from multiple viral strains is computationally integrated into optimized mosaic candidates that provide broad strain coverage.
02

Deep sequence analysis

Before any design begins, Ncode performs a multi-dimensional analysis of the sequence landscape. It does not optimize for a single metric, it assesses every candidate across the parameters that determine whether a sequence can become a viable product.

Structural integrity
Correct, stable 3D folding
Stability
Resistance to degradation
Expression potential
Efficient translation to target
Manufacturability
Reliable, cost-effective production
Ncode sequence analysis
03

RNA design & sequence optimization

Once the antigen is defined, Ncode designs the RNA construct by balancing what biology needs with what manufacturing requires, resolving the tension between competing dimensions to produce the best-suited sequence for each application.

Therapeutic efficacy RNA stability Translational efficiency Manufacturing feasibility

Why Ncode

Designed to perform — and to reach production.

Ncode is your one-stop shop for antigen design and sequence optimization. Whether you're starting from a blank sheet or already have a design in mind, Quantoom's team of experts works with you to refine your antigen and optimize it for real-world constraints: DNA manufacturability, RNA stability, protein expression, and therapeutic effect.

These aren't a checklist,  they're a system. A great antigen can be impossible to manufacture; a manufacturable DNA can refuse to express. One without the others doesn't work. Standalone tools can reach equivalent solutions, but they optimize one constraint at a time, so you design, test, fail, and start over, with every dead end landing on your bench. Ncode optimizes all four together, resolving the trade-offs before you run a single experiment.

If time, money, and quality are of the essence, Quantoom is your partner of choice.

Manufacturing in mind from day one

Where many tools optimize for expression alone, Ncode balances biological performance with DNA manufacturability and downstream RNA production constraints.

Embedded in a full-stack RNA platform

Every design decision connects to the next steps — from DNA template generation to RNA production and formulation — reducing handoffs and moving partners faster.

Adaptable across applications

From RNA optimization of an existing antigen to full antigen-to-construct generation — adapting to species, modality and development maturity.

Beyond theoretical design

Ncode has been validated through real-world use across real programs, not a concept, but a proven design engine.

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How to design a plasmid

Download our general plasmid design guidelines for the Ntensify® process.

How Ncode compares

Other tools solve pieces of the problem. Ncode resolves every constraint in one system, and hands you the result.

Ncode
Open tools
Commercial tools
What we optimize
Antigen design
Full
Full
None
DNA manufacturability
Full
Full
Full
RNA stability
Full
Full
Partial
Protein expression
Full
Full
Partial
Therapeutic effect
Full
Full
None
How you get there
One-stop shop
antigen to construct, one partner
Full
Partial
None
Your sequence stays yours
no third-party servers
Full
Partial
Partial
Exclusive to you
your sequence isn't resold
Full
None
Partial
Any species
we build the codon tables
Full
Partial
Partial
Handled for you
a service, not plumbing
Full
None
Partial
Concurrent optimization
all constraints in one pass
Full
None
None
Fully addressed Partial / caveats Not addressed