TAMARA — RNA-LNP formulation platform | Quantoom Biosciences
In partnership with Inside Therapeutics

TAMARA
RNA-LNP
formulation
platform

One system across your full R&D workflow
Efficiency: reusable chips & zero losses
Quick and intuitive
TAMARA RNA-LNP formulation instrument
Already adopted by leading research institutions worldwide
Moderna Servier Eli Lilly and Company University of Pennsylvania CNRS
TAMARA microfluidic formulation instrument with chip

RNA-LNP formulation platform

Streamlining RNA-LNP & nanoparticle manufacturing

Once your RNA and lipids are ready, TAMARA enables the reproducible formulation of RNA-LNPs from early screening to preclinical studies. Built for formulation R&D, it combines:

1
1 µg to 5 mg of encapsulated RNA per run
2
A reusable microfluidic chip with two mixer designs on one reversible chip
3
Zero formulation losses, >90% RNA recovery

What can TAMARA do?

Whether you’re screening lipid formulations or exploring different payload options, TAMARA adapts to your needs.

Nanoparticles you can formulate

A few of our core formulation capabilities

Lipid nanoparticles (RNA-LNP…)
Liposomes, micelles, polyplexes
Polymer & hybrid nanoparticles
Peptide nanoparticles

Payloads you can encapsulate

Most common cargos you can load

mRNA, saRNA, circRNA
siRNA, miRNA
CRISPR-Cas9
ASOs & DNA
Small molecules & peptides

Applications you can address

Wide range of therapeutic areas

Preventive and therapeutic vaccines
Gene editing & rare disease
Oncology
Personalized medicine
Consistency by design

Your LNP stays the same as you scale up

With TAMARA, a single instrument carries your formulation across the entire R&D workflow. Because the chip, the mixer and the process stay identical from a 0.2 mL screen to a 30 mL preclinical batch, your nanoparticle keeps the same size, PDI and encapsulation efficiency at every scale — so your in vivo readouts reflect the biology, not a change of instrument.

One system, 0.2 mL to 30 mL
1
0.2 mL
Screen
2
Optimize
Refine formulation
3
30 mL
Preclinical batch
Same size Same PDI Same EE
1 µg – 5 mg
encapsulated RNA per run
Up to
98%
encapsulation efficiency
Up to
>90%
encapsulation yields
PDI < 0.2
particle uniformity
CV < 5%
batch-to-batch
Microfluidic technology

The technology behind the speed

Microfluidic mixing is the reference method for RNA-LNP formulation. It allows for:

Best size control and reproducibility through flow condition control (TFR & FRR)
High encapsulation efficiency (EE >95%)
Excellent in vitro & in vivo performance
Accurate formulation from µL to mL volumes

Herringbone mixer

Fastest mixing for the smallest LNPs. Gold standard in RNA-LNP formulation.

Baffle mixer

Robust secondary-flow design for broader flexibility.

TAMARA microfluidic chip loaded in the instrument

Two minutes to understand TAMARA

An intuitive 3-step process, even for a first-time user. It’s that simple.

Watch the TAMARA 3-step process video
01Step one

Set

Choose your mixer and set the flow conditions for your target LNP.

02Step two

Pipette

Load your RNA and lipid phases directly — no priming, no dead volume.

03Step three

Run

Start the run and recover your RNA-LNPs, reproducibly, in minutes.

Efficiency

Make the most of every microgram

Once your RNA is ready, every microgram counts. TAMARA’s chip design avoids the dead-volume losses common to single-use systems, recovering more than 90% of your input RNA.

Reusable chips, cleaned between runs with a built-in protocol, also remove the recurring cost of disposable cartridges.

>90%
of input RNA recovered — no dead-volume losses.
Reusable chips, cleaned with a built-in protocol.
No recurring cost of disposable cartridges.
TAMARA reusable microfluidic chip

“It’s only through daily use that the true value of a machine becomes apparent. When PhD students consistently gravitate toward one device while overlooking others, it speaks volumes. TAMARA is in high demand — an endorsement in itself.

Prof. Raymond Schiffelers
Full Professor at UMC Utrecht · President, Nanomedicine European Technology Platform (ETPN) · Editor, IJP & JCR
See it in action

See TAMARA run, live

Book a demo with our team — online or at your lab — and see a full RNA-LNP formulation run from set-up to result.

One system across your full R&D workflow Reusable chips & zero losses Quick and intuitive