RNA Production
Next-generation scalable RNA manufacturing.
A construct-agnostic (sa)mRNA production solution — process, reagents, disposables and scalable equipment — engineered to compress timelines and cost from R&D to commercial supply.
RNA production
Four design principles work together to de-risk and scale your RNA program — an intensified process, ready-to-use reagent mixes, scale-less disposables and automated equipment.
- •Redesigned & optimized process for unparalleled RNA quality and yields.
- •Ready-to-use reagent mixes increasing standardization.
- •Scale-less disposables enabling µg to kg production.
- •Automated equipment improving reproducibility.
Redesigned and optimized process
A single-bead purification and optimized IVT & DSP deliver a high-quality RNA profile while minimizing impurities — validated by robust DoE across 2000+ reactions and 100+ constructs.
Cost-effective production of RNA drug substance
Quantoom Biosciences has developed an intensified process to consistently achieve a high-quality RNA profile at a fraction of the cost.
- ✓High IVT titer and capping efficiency
- ✓High RNA integrity with low dsRNA & residual pDNA
- ✓Consistent purification yield across constructs
Offering maximum flexibility in the design & scale-up
The intensified footprint collapses buffer prep, IVT and purification suites into a fraction of the space required by a conventional workflow.
Reducing the number of workflow steps
A single automated instrument replaces multiple pieces of equipment across upstream and downstream processing.
Download the general plasmid design guidelines
DNA design specifications and minimum quality criteria to be met for use in the Ntensify® process.
Our product line
One integrated process, scaling from bench-scale construct assessment to clinical and commercial supply.
Mixes of reagents
Ready-to-use, optimized reagent mixes — uridine, nucleotides and enzymes — are delivered in scalable formats designed to work seamlessly with the Ntensify® process, increasing standardization and reducing hands-on time.
Proprietary disposables
Scale-less consumables run the same process from µg to kg — removing scale-up steps and enabling a seamless path from research to commercial supply.
