Ncode

RNA sequence design for expression and manufacturability

The RNA design intelligence pillar of Quantoom's N-Force platform.

Converting antigens into RNA constructs optimized for biological performance and the practical realities of DNA template generation and RNA production.

+300

RNA designs generated on the platform

+100

tested in vitro & in vivo

100%

successfully inducing protein expression

What is Ncode?

Ncode is Quantoom's RNA design intelligence pillar of N-Force. It converts antigens into RNA constructs optimized for biological performance, DNA template generation, and RNA production.

Strand 01

Machine precision

State-of-the-art algorithms, computational models and AI-driven optimization explore vast sequence design spaces at a remarkable speed and scale.

Strand 02

Human intelligence

Every output is shaped by hands-on scientific review. Ensuring our platform products are biologically meaningful and practically viable, not just computationally optimal.

The first pillar of N-Force

Ncode

RNA design platform

Ntensify®

RNA production platform

Ncapsulate®

RNA delivery platform

Ncode is the design pillar of N-Force where every RNA production begins. It hands the new biologic off to Ntensify® for production at every scale and Ncapsulate® for delivery of the drug product.

Our capabilities

From sequence landscape to production-ready RNA. Three connected stages, one design engine.

Antigen design support

When the antigen is not yet defined, Ncode can support antigen design for selected applications. Bringing computational and biological expertise to the first critical step of an RNA-based treatment.

Personalized cancer treatments, neoantigen assembly

Starting from candidate neoantigens provided to us, our domain experts design the constraints that drive neoantigen assembly. Optimizing their encoding to maximize processing and generate RNA-ready sequences, patient by patient.

Animal health, mosaic antigen design

Viral diversity is one of the biggest obstacles in animal health vaccine development, and a single strain is rarely sufficient. Our platform addresses this with mosaic design approaches: sequence data from multiple viral strains is computationally integrated into optimized mosaic antigen candidates that provide broad coverage. This is not manual curation, it is a data-driven, algorithmically guided process that identifies the optimal combination of epitopes across strains.

Deep sequence analysis

Before design begins, Ncode evaluates the sequence landscape across the parameters that determine whether an RNA construct can become a viable product. It does not optimize for a single metric, it assesses the balance between expression potential, stability, structural behavior, DNA manufacturability, and downstream RNA production requirements.

Structural integrity

Correct, stable 3D folding

Stability

Resistance to degradation

Expression potential

Efficient translation to target

Manufacturability

Reliable, cost-effective production

RNA design & sequence optimization

Once the antigen is defined, Ncode designs the RNA construct by balancing what biology needs with what manufacturing requires. It optimizes across multiple, sometimes competing dimensions, expression, stability, manufacturability, and process compatibility, to generate RNA sequences that are not only computationally strong, but practically usable in development and production.

Therapeutic efficacyRNA stabilityTranslational efficiencyManufacturing feasibility

Why Ncode

Four reasons partners choose Ncode: manufacturing-ready design, full-stack integration, adaptability across programs, and real-world validation.

Manufacturing in mind from day one

Where many tools optimize for expression alone, Ncode balances biological performance with DNA manufacturability and downstream RNA production. Sequences designed not only to perform, but to reach real-world production.

Embedded in a full-stack RNA platform

Not an isolated design pillar. Every decision connects to DNA template generation, RNA production, and formulation, reducing handoffs and helping partners move faster from target to RNA product.

Adaptable across applications, species, and partner maturity

From RNA optimization of an existing antigen to full antigen-to-construct generation, adapting to species, modality, and development stage.

Beyond theoretical design

Validated across real programs: +300 RNA designs generated, +100 tested in vitro and in vivo, all successfully inducing protein expression.

How to design a plasmid

Download our general plasmid design guidelines for the Ntensify® process.

mRNAPlasmid design guidelines · PDF saRNAPlasmid design guidelines · PDF

The full picture

How Ncode compares

Other tools solve pieces of the problem. Ncode resolves every constraint in one system and hands you the result.

Ncode

Open tools

Commercial tools

What we optimize

Antigen design

Full

None

DNA manufacturability

Full

RNA stability

Full

Partial

Protein expression

Full

Partial

Therapeutic effect

Full

None

How you get there

One-stop shop

antigen to construct, one partner

Full

Partial

None

Your sequence stays yours

no third-party servers

Full

Partial

Exclusive to you

your sequence isn't resold

Full

None

Partial

Any species

we build the codon tables

Full

Partial

Handled for you

a service, not plumbing

Full

None

Partial

Concurrent optimization

all constraints in one pass

Full

None

Fully addressedPartial / caveatsNot addressed

Ready to reinvent your RNA program?

Talk to our team about how the N-Force toolbox can compress your timelines from sequence to dose.

Book a call →