LNP formulation equipment
Automated formulation with integrated mixing, purification and in-line control
mRNA-LNP formulation is a complex process, requiring multiple unit operations and elaborated purification steps. Large scale solution exist, but can sometimes be cost-prohibitive
Combining jet mixing and patented TFF-based purification in a single equipment, Ncapsulate mixi facilitates formulation by reducing the amount of unit operations and associated handling operations. It is tailored to the Ntensify midi and can operate at GMP-scale.
CONTINUOUS JET MIXING
Jet-mixer generate highly turbulent flow, maximizing encapsulation efficiency while maintaining low PDI.
TFF BASED INTEGRATED PURIFICATION
The use of a patented TFF-system prevents membrane clogging and fouling, reducing the risk of required manual intervention and potential decrease of quality attributes
IN-LINE CONTROL
The ground-breaking uses SRDLS to offer non-invasive, accurate particle size measurements
TAILORED FOR THE NTENSIFY MIDI
Ncapsulate mixi is tailored to the throughput of the Ntenisfy midi and can formulate batches from 1 to 4g of RNA
RNA formulation chemistries
Proprietary formulation chemistries with demonstrated track record in mRNA & saRNA formulation, from infectious disease vaccination to personalized cancer vaccine
Quantoom has developed a new class of lipids-like with adaptable heads and interchangeable tails, allowing for customization to achieve specific functionalities.
This versatility enables us to develop a diverse library of lipids-like molecules, each tailored to meet unique therapeutic needs.
Our lipid-like chemistry are free from third-party IP constraints, opening a new possibilities for RNA delivery in an IP-dense market.
DEMONSTRATED SAFETY
Following extended in-vivo evaluation
INCREASED ANTIGEN EXPRESSION
When formulating saRNA, compared to gold-standard formulation
VALIDATED POTENCY
In a murine rabies model, confirming real-world potential
FLEXIBLE LICENSING OPTIONS
Enabling cost-effective synthesis for human health applications
PLATFORM-LIKE CHEMISTRY
The structure of our QCX can be tailored to meet specific requirements
FREE OF ANY THIRD-PARTY IP
Ensuring a clear path to commercialization